Doublecortin immunoreactive (DCX+) cells in representative adult human temporal (A–F) and frontal (G–M) cortices prepared from surgically removed biopsies. Distinctly stained DCX+ cells exist in layer II, most of which are small bipolar (A–F) and a few multipolar (K, M). Medium-sized DCX+ cells occur across the cortex, display weak to moderate immunoreactivity, are either bipolar or multipolar, and have short processes (arrows, I). Some cells also occur in pairs (double arrows in I, L). Scale bar = 200 μm in A applying to A, D, G, H, K, L; 100 μm for B, E and 50 μm for C, F, I, J, M.