Fig. 2.

Vacuolization and glycosphingolipid deposits in Fabry nephropathy. (A) The glomerulus shows vacuolization of podocytes (arrowheads), and mild corrugation of glomerular basement membranes, with periglomerular and interstitial fibrosis (periodic acid-Schiff, x400). (B) The glomerulus shows massive expanded deposits in most podocytes (arrowheads) and also in mesangial and endothelial cells and parietal epithelial cells in this male Fabry patient (toluidine blue, ×400). (C) The glomerulus shows occasional small deposits in podocytes (arrowheads) and rare deposits in mesangial areas in this female patient (toluidine blue, ×400). (D) There are prominent deposits in some proximal tubular cells and peritubular capillary endothelium (toluidine blue, ×1000). (E) Numerous deposits in distal tubules and very rare deposits in proximal tubules. The vascular smooth muscle of a large artery (top left corner) also shows deposits, as do parietal epithelial cells lining the Bowman's capsule (bottom) (toluidine blue, ×1000). (F) Numerous deposits in distal tubules with rare deposits in proximal tubules and frequent deposits in peritubular capillaries and interstitium (toluidine blue, ×200).