Table 5.
Kidney morphologic findings in Fabry patients
| All (n = 59) | Male (n = 35) | Female (n = 24) | P-valuea | |
|---|---|---|---|---|
| Distal tubule inclusions | 42/14 (75.0%) | 28/6 (82.4%) | 14/8 (63.6%) | NS |
| Proximal tubule inclusions | 20/35 (36.4%) | 16/18 (47.1%) | 4/17 (19.0%) | 0.046 |
| Peritubular capillary inclusions | 33/23 (58.9%) | 26/8 (76.5%) | 7/15 (31.8%) | 0.002 |
| Vascular intimal inclusions | 19/19 (50.0%) | 16/9 (64.0%) | 3/10 (23.1%) | 0.038 |
| Vascular medial inclusions | 25/13 (65.8%) | 17/8 (68.0%) | 8/5 (61.5%) | NS |
| Arteriolar hyalinosis (light microscopy sections) | 34/21 (61.8%) | 22/12 (64.7%) | 12/9 (57.1%) | NS |
| Arterial hyalinosis (light microscopy sections) | 22/33 (40.0%) | 9/25 (26.5%) | 13/8 (61.9%) | 0.012 |
Data are presented as present/absent and percentage present/(present + absent);
Excluded cases are those that could not be scored due to insufficient sampling for that variable. Lesions scored on semi-thin sections except as noted.
aFisher exact two-tailed test statistic, females compared to males;
NS, non-significant.