FIG. 5.

Acute oral DON exposure differentially affects hepatic mRNA expression of IGF1 ternary complex partners. Mice were orally gavaged with 12.5 mg/kg bw DON or PBS vehicle treatment (VH) and then treated with GH i.p 2 h later. At 3 and 6 h after DON administration, liver was analyzed by real-time PCR for (A) IGFALS, (B) IGF1, and (C) IGFBP3. Data are mean ± SEM (n = 4) of mRNA change in target relative to VH. Means with asterisks differ from VH at the specified time interval (p < 0.05).