A: Reduced incidence of prostate cancer in LF diet group compared to the HF diet group. The prostates dissected from 7 month old Hi-Myc mice were analyzed in H&E stained histologic sections at two different depths by a pathologist blinded to the treatment groups. N=28 for LF group and N=33 for HF group. P=0.042 calculated by the Fisher exact test.
B: Prostate epithelium with high grade prostatic intraepithelial neoplasia (PIN) characterized by tufted epithelial cells with prominent nucleoli.
C: Invasive prostate cancer infiltrating into the adjacent fibroadipose tissue.