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. Author manuscript; available in PMC: 2010 Jul 13.
Published in final edited form as: Cancer Res. 2008 Apr 15;68(8):3066–3073. doi: 10.1158/0008-5472.CAN-07-5616

Figure 1. Effect of dietary fat reduction on transition from PIN to cancer in Hi-Hi-Myc-mouse prostate.

Figure 1

Figure 1

A: Reduced incidence of prostate cancer in LF diet group compared to the HF diet group. The prostates dissected from 7 month old Hi-Myc mice were analyzed in H&E stained histologic sections at two different depths by a pathologist blinded to the treatment groups. N=28 for LF group and N=33 for HF group. P=0.042 calculated by the Fisher exact test.

B: Prostate epithelium with high grade prostatic intraepithelial neoplasia (PIN) characterized by tufted epithelial cells with prominent nucleoli.

C: Invasive prostate cancer infiltrating into the adjacent fibroadipose tissue.