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. Author manuscript; available in PMC: 2010 Jul 13.
Published in final edited form as: J Biol Chem. 2005 Aug 22;280(45):37782–37789. doi: 10.1074/jbc.M505278200

FIGURE 8. PAPP-A augments C2C12 myoblast proliferation via an IGF-dependent mechanism.

FIGURE 8

DMEM/5% FCS supplemented with effectors at the indicated concentrations was added to the C2C12 cell cultures, and cellular proliferation was measured using AlamarBlue assay after 48 h of incubation. Data presented here show that PR-BP4 treatment completely blocked the PAPP-A-induced proliferation of C2C12 myoblasts (*, p <0.05 versus PAPP-A alone).