TABLE 2.

Definition of terms used in the proposed diagnostic criteria

Major criteria Positive blood cultures Typical causative agents in two different cultures: ○ Viridans group streptococcus, Streptococcus bovis, HACEK group ○Staphylococcus aureus, Enterococcus species – in the absence of a primary source Continuous positive blood cultures ○Positive cultures taken at least 12 h apart ○Three of three positive cultures, or majority of four or more cultures, when there is at least 1 h between collection of the first and last cultures Echocardiographical findings Intracardial pendulous mass attached to the lead or in the endocardial structure in contact with the lead Abscess in contact with the lead

Minor criteria Temperature greater than 38°C Vascular findings: Arterial embolus, septic pulmonary infarcts, mycotic aneurysm, intracranial hemorrhage, Janeway lesions Immunological findings: Glomerulonephritis, Osler’s nodes, Roth’s spots Echocardiography: Findings supporting CDE that do not qualify as major criteria Microbiology: Positive blood cultures that do not qualify as major criteria

CDE Cardiac device-related endocarditis; HACEK Haemophilus species (Haemophilus parainfluenzae, Haemophilus aphrophilus and Haemophilus paraphrophilus), Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens and Kingella kingae. Data from reference 1