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. Author manuscript; available in PMC: 2010 Jul 13.
Published in final edited form as: Sci Transl Med. 2010 Apr 21;2(28):28ra29. doi: 10.1126/scitranslmed.3000522

Fig. 3.

Fig. 3

SUR1 up-regulation is associated with the transcription factor Sp1. (A) Immunohistochemical localization of SUR1 24 hours after hemicord T9 SCI in wild-type mice. Left panel is a montage of images, with positive immunolabeling indicated as white pseudocolor. Circle denotes impact site. Right panels show high-magnification images of injured spinal cord colabeled for NeuN, OSP, or von Willebrand factor (all green), indicative of neurons, oligodendrocytes, or microvascular endothelium, respectively. Superimposed images are shown in the right column. Images shown are representative of findings in three mice. (B) Immunohistochemical localization of SUR1 (red) in capillaries colabeled for von Willebrand factor (green) after hemicord C7 SCI in rat. (C) Immunohistochemical localization of Sp1 24 hours after SCI in mouse, rat, and human, as indicated. The left upper panel is a montage of images after hemicord T9 SCI in a wild-type mouse, with positive immunolabeling indicated in white. High-power views of penumbral fields from mouse, rat, and human are also shown. Nuclei were labeled with 4′,6-diamidino-2-phenylindole (DAPI). Pink nuclei indicate nuclear localization of Sp1. Arrows point to capillaries. Asterisks indicate neurons. Scale bars, 50 μm (C), 100 μm [(A) and (B)].