. Author manuscript; available in PMC: 2011 Mar 1.

Published in final edited form as: J Magn Reson Imaging. 2010 Mar;31(3):538–548. doi: 10.1002/jmri.22068

Table 2. Confidence intervals, ΔADC thresholds, and cell density estimates for various mixtures of tissue types.

NAWM = normal-appearing white matter; NAGM = normal-appearing gray matter, NAWM+NAGM = mixture of normal-appearing white and gray matter; NAWM+NAGM+CSF = mixture of normal-appearing white matter, gray matter, and cerebrospinal fluid

Tissue Type	Level of Significance [P-Value]	Confidence Interval [%]	Δ ADC Threshold [×10^-3 mm²/s]	Δ Cellularity (95% C.I.) [Nuclei/mm²]	Δ Cellularity (95% C.I.) [Nuclei/HPF]	9L Glioma (ref 3) [Nuclei/HPF]	Human Glioma (ref 20) [Nuclei/HPF]
NAWM	*0.0250*	*95%*	*0.25*	*2475 (1933-3444)*	*11.67 (9.11-16.22)*	6.94	6.25
NAGM	*0.0250*	*95%*	*0.31*	*3069 (2397-4269)*	*14.47 (11.30-10.12)*	8.61	7.75
NAWM+NAGM	*0.0250*	*95%*	*0.40*	*3960 (3094-5510)*	*18.67 (14.58-25.96)*	11.11	10.00
NAWM+NAGM+CSF	*0.0250*	*95%*	*0.75*	*7426 (5800-10331)*	*35.01 (27.33-48.67)*	20.83	18.75
Standard Threshold	*0.0250*	*95%*	0.55	*5446 (4254-7576)*	*25.68 (20.04-35.69)*	15.28	13.75