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Macroscopic and histological findings 4 weeks after surgery. a and h Untreated defects. b and i Defects treated with the gelatin sponge only (no E-rhBMP-2). c and j Defects treated with 1 μg E-rhBMP-2. d and k Defects treated with 5 μg E-rhBMP-2. e and l Defects treated with 10 μg E-rhBMP-2. f and m Defects treated with 20 μg E-rhBMP-2. g and n Defects treated with 40 μg E-rhBMP-2. i-m Toluidine blue staining, original magnification ×20
