FIGURE 3.
Changes in hepatic CYP2E1 protein expression following weight loss are independently associated with resolution of dyslipidemia (P = 0.013). CYP2E1 protein content was measured in liver biopsies by immunohistochemistry followed by digital image quantification and is represented as the percent (%) of the total liver biopsy area that stained positive for CYP2E1. Of the 20 subjects who participated in the study, 18 had dyslipidemia prior to bariatric surgery. After weight loss, resolution of dyslipidemia was observed in 13 patients (72%) but remained in 5 subjects (28%).