FIGURE 4.
Baseline hepatic CYP3A4/5 protein expression is independently associated with hepatic CYP2E1 protein content prior to bariatric surgery and weight loss (r = 0.564; P = 0.010). Hepatic CYP protein content was measured by immunohistochemistry followed by digital image quantitation of protein expression in 20 subjects before and after bariatric surgery-induced weight loss. CYP protein expression is represented as the percent (%) of the total liver biopsy area that stained positive for the CYP protein of interest.