Table I.

Statistical results on real MRI data

Quantity	Proposed algorithm	FreeSurfer
Mean change for all subjects	−0.69%	−0.35%
Mean change for AD subjects	−1.42%	−1.15%
Mean change for normal subjects	−0.19%	+0.20%
SD of change for all subjects	3.42	2.68
SD of change for AD subjects	3.52	2.40
SD of change for normal subjects	3.39	2.82
Group separation	0.36	0.50

The relative change in the mean thickness as measured over a 1‐year interval.

Group separation = (Mean for normal − Mean for AD)/(SD for all).