Table 5. Early Cytokines in relation to BPD or Death: Cytokines in model are averages among all samples within 0–3 days.

All variables selected by stepwise regression at p<0.2 are shown, and the variables significant at p<0.05 by subsequent multivariable logistic regression are shown in bold.

BPD or Death – Early Cytokines Averages (0–3 Days)
N = 1003 (577 with outcome) R-square = 0.32 (0.43 max-rescaled)
Variable	OR	95% CI	p-value
IL-8 – 100,000 pg/ml	14.98	1.29 – 173.9	0.03
RANTES – 100,000 pg/ml	0.72	0.56 – 0.91	<0.01
BDNF – 10,000 pg/ml	0.87	0.73 – 1.02	0.09
IL-10 – 1,000 pg/ml	2.03	1.11 – 3.72	0.02
MMP-9 – 1,000,000 pg/ml	1.06	0.99 – 1.13	0.12
TREM1 – 10,000 pg/ml	0.53	0.27 – 1.05	0.07
Gestational Age *	0.62	0.55 – 0.69	<0.0001
SGA	1.87	1.09 – 3.19	0.02
Gender – Female vs Male *	0.54	0.40 – 0.74	0.0001
IMV	13.61	3.97 – 46.59	<0.0001
Race – Nonblack vs Black *	0.82	0.58 – 1.15	0.24
Center *	varies		<0.0001

Odds Ratios (OR) are expressed per magnitude of change of the variable (e.g. IL-1β-1,000 pg/ml indicates that OR are per 1,000 pg/ml change in IL-1β concentration;

^*: variables forced into model.