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Virus growth and viral mRNA in B6, SJL, and cB61ba mice. Mice were inoculated i.p. with MHV-A59 (105 PFU/100 μl), and tissues shown were collected on days 2, 4, and 7. Virus titers (A) and the relative levels of viral mRNA and genomic RNA (B) in those tissues were measured by plaque assay and real-time PCR, respectively. All B6 mice died 5 to 7 days after virus inoculation. Error bars represent standard deviations of the results from four independent samples.
