FIG. 3.

Neuronal cell loss within the hippocampus in C3-deficient mice infected with DA virus. Neuronal cell loss was scored as described in Materials and Methods for mice sacrificed on days 3, 7, and 10 p.i. Neuronal cell loss was significantly greater in the C57BL/6 mice with seizures on day 7 p.i. than in C57BL/6 mice without seizures on days 3 and 7 p.i. The C3-deficient mice (C3^−/−) with seizures had significantly greater neuronal cell loss than the C3-deficient mice without seizures on day 10 p.i. ‡, P < 0.05; *, P < 0.01. Results are depicted as means plus SEMs (error bars) for groups with 3 to 18 mice per group.