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Choline infusion at 5 mg kg−1 h−1 increases (a) heat latency and (b) pressure withdrawal in wild-type and heterozygous mice for the α7 deletion (P<0.001 heat, P<0.001 pressure). Choline did not affect heat latency and pressure threshold in mice-lacking α7 nicotinic acetylcholine receptors and their response was significantly different from that of wild-type mice (*P<0.05 heat, **P<0.01 pressure; mean (sd) n=9 WT, 14 HET, 4 KO).
