Table 3.
Univariate and Multivariate Cox Regression Models of DFS and RR for Standard-Risk Patients
| Factor | DFS |
RR |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Univariate model | ||||||
| Low v high VLA-4* | 2.33 | 1.19 to 4.56 | .014 | 2.59 | 1.26 to 5.33 | .010 |
| Age, years | ||||||
| 0-2 | 1.00 | 1.00 | ||||
| 3-10 | 0.67 | 0.34 to 1.31 | .236 | 0.61 | 0.29 to 1.25 | .177 |
| ≥ 11 | 1.02 | 0.59 to 1.77 | .949 | 0.91 | 0.50 to 1.64 | .741 |
| WBC ≥ v < 100,000/μL | 0.73 | 0.33 to 1.60 | .429 | 0.85 | 0.38 to 1.87 | .679 |
| MRD positive at end of induction I | 2.50 | 1.32 to 4.76 | .005 | 2.63 | 1.35 to 5.13 | .005 |
| EMD positive at study entry | 0.85 | 0.34 to 2.12 | .729 | 0.79 | 0.28 to 2.18 | .644 |
| Multivariate model | ||||||
| Low VLA-4 | 5.05 | 1.72 to 14.8 | .032 | 6.86 | 2.05 to 22.9 | .002 |
| Age | ||||||
| 3-10 years | 0.49 | 0.13 to 1.88 | .297 | 0.35 | 0.08 to 1.49 | .154 |
| ≥ 11 years | 0.58 | 0.17 to 1.92 | .368 | 0.42 | 0.12 to 1.51 | .181 |
| WBC ≥ 100,000/μL | 0.57 | 0.19 to 1.75 | .329 | 0.60 | 0.19 to 1.90 | .386 |
| MRD positive at end of induction I | 2.78 | 1.19 to 6.48 | .018 | 2.87 | 1.15 to 7.17 | .024 |
| EMD positive at study entry | 1.35 | 0.25 to 7.32 | .731 | 1.54 | 0.27 to 8.87 | .629 |
Abbreviations: DFS, disease-free survival; RR, relapse rate; VLA-4, very late antigen-4; MRD, minimal residual disease; EMD, extramedullary disease.
*
Nonproportional hazards but accelerated failure time models yielded qualitatively similar results.