Table 4.

DFS and OS by MMR and Treatment Status in Univariate and Multivariate Models Adjusted for Stage, Sex, and Age in the Pooled Data Set

MMR and Treatment Status	No. of Patients (N = 1,027)	DFS							OS
		5-Year Rate (%)	Univariate			Multivariate			5-Year Rate (%)	Univariate			Multivariate
			HR	95% CI	P	HR	95% CI	P		HR	95% CI	P	HR	95% CI	P
Untreated	515
dMMR	79	80	0.41	0.24 to 0.70	.001	0.51	0.29 to 0.89	.009	85	0.42	0.24 to 0.72	.001	0.47	0.26 to 0.83	.004
pMMR	436	56							66
Treated	512
dMMR	86	70	0.98	0.64 to 1.51	0.93	0.79	0.49 to 1.25	.30	73	0.95	0.62 to 1.48	.83	0.78	0.49 to 1.24	.28
pMMR	426	67							74
dMMR	165
Untreated	79	80	1.61	0.84 to 3.10	.15	1.53	0.78 to 3.04	.22	85	1.58	0.81 to 3.09	.18	1.56	0.77 to 3.16	.21
Treated	86	70							73
pMMR	862
Untreated	436	56	0.69	0.55 to 0.86	.001	0.70	0.56 to 0.88	.002	66	0.73	0.58 to 0.91	.006	0.74	0.59 to 0.94	.01
Treated	426	67							74

Abbreviations: DFS, disease-free survival; OS, overall survival; MMR, DNA mismatch repair; HR, hazard ratio; dMMR, defective DNA mismatch repair; pMMR, proficient DNA mismatch repair.