TABLE 2.
Over-represented GO terms for genes significantly down-regulated in VP16-ERRγ mice
Fold enrichment indicates the number of genes actually seen versus expected in the list given the distribution in the mouse genome of a specified GO term. p value indicates EASE score (p value of modified Fisher's exact test).
| GO category | Term | Fold enrichment | p value |
|---|---|---|---|
| Biological process | Post-translational protein modification | 2.05 | 8.85E-27 |
| Ubiquitin cycle | 2.81 | 7.78E-23 | |
| Protein amino acid phosphorylation | 1.67 | 3.73E-06 | |
| Chromatin modification | 2.44 | 3.99E-06 | |
| Molecular functions | Transcription factor binding | 2.51 | 1.53E-08 |
| Magnesium ion binding | 1.93 | 4.71E-06 | |
| Transforming growth factor β receptor activity | 8.39 | 6.20E-05 | |
| Cytoskeletal protein binding | 1.77 | 6.47E-05 | |
| Ubiquitin thiol esterase activity | 2.95 | 4.16E-04 | |
| Cellular compartments | Contractile fiber part | 3.56 | 3.52E-06 |
| Myofibril | 3.33 | 9.76E-06 | |
| Nucleoplasm part | 1.63 | 5.92E-05 | |
| Endoplasmic reticulum | 1.52 | 1.05E-04 | |
| Histone deacetylase complex | 4.82 | 1.24E-04 |