FIGURE 3.

Effect of Fsk and CFTR_inh-172 on the whole cell Cl⁻ currents recorded for each CFTR mutant. A, representatives traces of whole cell Cl⁻ currents elicited by stepping from holding potential of −40 mV to a series test potentials from −100 to +100 mV in 20-mV increments. B, corresponding current densities (pA/pF) obtained by current-voltage relationships normalized by cell capacitance (▵, basal; □, 10 μm Fsk; ●, 10 μm Fsk + 10 μm CFTR_inh-172). Schemes on the right side indicate the position of each amino acid and its substitution on the β₅c/β₆c hairpin. Error bars, S.E. The bottom traces were recorded in F508del-expressing cells.