Kinetic of activation of whole cell Cl− currents for wt, G622D, and G628R CFTR. A, representative time course of whole cell Cl− current densities at 40 mV recorded in presence of 1 μm Fsk and 1 μm +50 μm MPB-91. B, histograms of the corresponding means of global current densities. ns, nonsignificant difference; *, p < 0.05; **, p < 0.01; ***, p < 0.001. Error bars, S.E.