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. 2010 May 17;285(29):22706–22712. doi: 10.1074/jbc.M110.134114

FIGURE 5.

FIGURE 5.

Elephant shark ASIC1. A, wild type (wt) EFS ASIC1 produces small and fast currents. B, substitutions of residues in the β1-β2 linker for the corresponding SQL of rat results in large currents. C, comparison of normalized currents of wild type and SQL mutant EFS channels. Red lines are fits of the currents to Equation 2. Wild type versus SQL mutant: τa 3 versus 16 ms, and τd 17 versus 140 ms. E, apparent proton affinities of EFS-SQL. E, Western blot of surface biotinylated proteins from 15 oocytes expressing the corresponding channels. The blot was probed with a V5 antibody.