TABLE 1.

GPI anchor analogues reduced the PrP^Sc content of ScN2a and SMB cells

ScN2a or SMB cells were treated daily with GPI anchor analogues as shown for 7 days, and the amount of cell-associated PrP^Sc was determined using a PrP ELISA. Values given are the mean average amount of PrP^Sc (pg/10⁶ cells) ± S.D., n = 12.

Treatment	PrPSc (pg/106 cells)
	ScN2a	SMB
None	2128 ± 95	6057 ± 639
Vehicle control	2096 ± 140	5988 ± 458
1 μm glucosamine-PI	<50a	<50a
1 μm glucosamine-O-methyl inositol octadecyl phosphate	186 ± 120a	748 ± 161a
50 μm glucosamine	2318 ± 92	5789 ± 634
50 μm galactosamine	1988 ± 221	6255 ± 589
50 μm galactose	2090 ± 320	6425 ± 663
50 μm mannose	2150 ± 337	6271 ± 713

^a Amount of PrP^Sc is significantly less than that of vehicle-treated cells (p < 0.01).