TABLE 3.
Glucosamine-PI altered the cholesterol distribution in ScGT1 cells
The amount of cholesterol and cholesterol esters (measured after 24 h) and PrPSc (measured after 7 days) in 106 ScGT1 cells treated with 200 μm mevalonate, 1 μm glucosamine-PI, 100 μm DEUP, or a combination of 1 μm glucosamine-PI and 100 μm DEUP is shown. Cholesterol, cholesterol ester, and PrPSc values are the mean average ± S.D., n = 12.
| Treatment | Cholesterol | Cholesterol esters | PrPSc |
|---|---|---|---|
| ng/106 cells | ng/106 cells | ng/106 cells | |
| Vehicle | 528 ± 42 | 185 ± 29 | 9.8 ± 1.2 |
| Mevalonate | 543 ± 38 | 296 ± 35 | 10.1 ± 1.4 |
| Glucosamine-PI | 754 ± 60 | 18 ± 10 | <0.05 |
| DEUP | 554 ± 41 | 169 ± 35 | 9.5 ± 0.9 |
| Glucosamine-PI + DEUP | 566 ± 51 | 164 ± 36 | <0.05 |