FIGURE 1.
Reduced LKB1 expression in endothelial cells isolated from Lkb1flox/+;Tie2Tg/+ (heterozygous LKB1-KO) mice. Upper, Western blot analysis for LKB1, Cre, and α-tubulin in endothelial cells isolated from lung of Lkb1flox/+;Tie2+/+, Lkb1flox/+;Tie2Tg/+, and Lkb1flox/flox;Tie2+/+ mice. Lower, histogram indicating LKB1 expression reproducible in isolated lung endothelial cells from Lkb1flox/+;Tie2Tg/+ mice (n = 6 in each group).