FIGURE 2.

Comparisons of CYP2E1 complexes with indazole (yellow), ω-imidazolyl octanoic fatty acid (green), ω-imidazolyl decanoic fatty acid (cyan), and ω-imidazolyl dodecanoic fatty acid (magenta). A, superposition of all four complexes. B, CYP2E1 interactions with the carboxylate termini of imidazolyl-fatty acids via Asn²⁰⁶ (octanoic, green; decanoic, cyan) or via contacts with both the G helix backbone and His¹⁰⁹ (dodecanoic, magenta). C, total omit map of ω-imidazolyl octanoic fatty acid contoured at 0.9 σ. D, total omit map of ω-imidazolyl decanoic fatty acid contoured at 1.0 σ. E, total omit map of ω-imidazolyl dodecanoic fatty acid contoured at 0.9 σ.