FIGURE 6.

Podocyte-specific Cfl1^−/− mice develop foot process spreading by 8 months of age. A, scanning EM of mouse kidney sections at the indicated postnatal age. There is evidence of foot process spreading by 8 months of age. There is evidence of fine finger-like projections from the podocyte cell bodies and processes at 6 months of age. B, transmission EM of Cfl1^−/− and Cfl^+/+ mice at 9 months. C, slit diaphragm frequency in wild type and Cfl^−/− mice at the indicated ages. D, histologically, hematoxylin and eosin staining of kidney sections from Cfl1^−/− and Cfl^+/+ mice show no evidence of scarring even at 9 months of age, when the mouse are significantly proteinuric. E, serum creatinine concentration in mutant mice compared with control. NS, not significant. Error bars, S.E.