FIGURE 6.

CTαLKO mice are not protected from HF diet-induced obesity. Data are means ± S.E. A, liver histology: tissue was fixed in 10% buffered-formalin and stained with hematoxylin and eosin. A representative picture of liver sections from four individual mice/group is shown. B, body weight of 8-week-old male floxed (control) and CTαLKO mice (n = 6) before and after being fed the HF diet for 10 weeks. C, oxygen consumption: male floxed and CTαLKO mice (n = 6) that had been fed the HF diet for 8 weeks were acclimatized for 24 h in an Oxymax Lab Animal Monitoring System, and indirect calorimetry measurements were taken every 13 min over a 24-h period. D, glucose tolerance test: 2 g of glucose/kg of body weight was administered by intraperitoneal injection to mice (n = 6) that had been fed the HF diet for 9 weeks. Blood glucose was measured at indicated times.