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. 2010 May 7;285(29):22403–22413. doi: 10.1074/jbc.M110.108514

FIGURE 7.

FIGURE 7.

Metabolic phenotype of Pemt−/− mice fed the HF diet is reversed by choline supplementation. Data are means ± S.E. A, body weight of 8-week-old male Pemt+/+ and Pemt−/− mice (n = 8–12) before (Initial) and after (Final) being fed the HFCS diet for 10 weeks. B, insulin tolerance test: 0.8 unit/kg body weight of human insulin was administered to mice that had been fed the HFCS diet for 9 weeks by intraperitoneal injection. Blood glucose was measured (n = 10–12). C, glucose tolerance test: 2 g of glucose/kg of body weight was administered by intraperitoneal injection to mice that had been fed the HFCS diet for 9 weeks. Blood glucose was measured (n = 8–12). D, oxygen consumption: Pemt+/+ and Pemt−/− mice that had been fed the HFCS diet for 8 weeks (n = 5) were acclimatized for 24 h in an Oxymax Lab Animal Monitoring System, and indirect calorimetry measurements were taken every 13 min over a 24-h period.