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Models of a steric switch designed at the Gαi1 – GoLoco interface (design #2). A) Wild type interface. B) The mutations S252L and K248E are predicted to create a clash at the interface between L503 and L252 that is accommodated by L503K (panel C). The predicted contribution of electrostatics to binding energy is reduced in the final design by rearrangement of R506 to accommodate K503.
