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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Proteins. 2010 Mar;78(4):1055–1065. doi: 10.1002/prot.22631

Figure 6.

Figure 6

Design of two polar to non-polar switches at the interface of E6AP (yellow) and UbcH7 (purple). Panels A–C: the mutation E60L is compensated with T662F and Q661W (design #7). Panels D–F: the mutation K96S is compensated with D641K (design #8). Despite only involving polar amino acids, design #8 is classified as polar to non-polar because a salt bridge interaction in the WT (K96 with D641) is replaced with hydrophobic interactions between the methylene groups on K641, the beta carbon of S96 and the side chain of proline 97.