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. 2010 Jul 13;5(7):e11528. doi: 10.1371/journal.pone.0011528

Figure 6. TrkB agonists are robust antidepressants.

Figure 6

(A) Forced swim test. 2–3-month-old Male mice (n = 8 mice/group) were treated with imipramine (20 mg/kg), deoxygedunin (5 mg/kg), 7,8-DHF (5 mg/kg) and vehicle solvent saline by intraperitoneal injection for 5 days, and subjected to a forced swim test (6 min, immobility recorded in the last 4 min). (B) Forced swim test with TrkB F616A knockin mice. Male TrkB knockin mice were given the regular drinking water or 1NMPP1 containing drinking water one day before the drugs. Deoxygedunin/1NMPP1 group is significantly different from the water group but not from control in 1NMPP1. Data are presented as mean ± SEM of n = 8–10 mice/group (**P<0.01 and ***P<0.001 against vehicle control group, One-way ANOVA, Dunnett's test).