Table 2. Outcome of randomized controlled trials of pediatric HCV therapy.

Author/Year/Country	Group A Therapy Incomplete	Group B Therapy Incomplete	Group A SVR	Group B SVR	Group A Adverse Effects	Group B Adverse Effects
1. Iorio 1995, Italy	Discontinued in 1 child in first month from ALT flare-up and in 5 others at 6 months since no response in ALT	Not applicable as no therapy given	5 of 11 (45%) at 30 months	1 of 11 (9%) at 30 months	Transient influenza-like syndrome in all patients;other symptoms included anorexia, asthenia, irritability, headache, abdominal pain, and leukopenia	Not reported
2. Bortolotti, 1995, Italy	Discontinued in 2 children from ALT flare-up, in 1 child from febrile seizure, and 1 since no response in ALT	Not applicable as no therapy given	9 of 13 (69%) at 24 months	0 of 13 (0%) at 24 months	Transient influenza-like syndrome in all patients;Other symptoms included pruritus, weight loss, and leukopenia	Not reported
3. Fried 2002, USA	Not reported	Not reported	10 of 17 (59%) at 72 weeks	Not reported	Not reported	Not reported
4. Schwarz 2008, USA	Discontinued in 2 children	Discontinued in 4 children	29 of 55 (53%) at 72 weeks	15 of 59 (21%) at 72 weeks	Not reported	Not reported