Table 2. Summary of difference in allelic variation at the IFIH1 locus.
Gene | SNP | Alleles | Tissue | Mean allelic ratio DNA ± SEMa | Mean allelic ratio cDNA ± SEMa | pb | Powerc |
IFIH1 | rs1990760 | T/C | LCL | 1.0000±0.0077 | 1.0029±0.0106 | 0.8477 | 100.0% |
IFIH1 | rs1990760 | T/C | Thymus | 1.0000±0.0596 | 1.0855±0.0341 | 0.2002 | 99.9% |
IFIH1 | rs1990760 | T/C | Pancreas | 1.0000±0.1009 | 1.0630±0.0791 | 0.6334 | 70.7% |
GCA | rs7587426 | C/T | LCL | 1.0000±0.0415 | 1.0939±0.0637 | 0.2373 | 99.6% |
GCA | rs7587426 | C/T | Thymus | 1.0000±0.0435 | 0.9999±0.0427 | 0.9994 | 100.0% |
GCA | rs7587426 | C/T | Pancreas | 1.0000±0.1751 | 0.8840±0.0429 | 0.4393 | 36.1% |
FAP | rs2075302 | T/C | LCL | could not be detected by PCR, not expressed in B lymphocytes | / | / | |
FAP | rs2075302 | T/C | Thymus | 1.0000±0.0375 | 0.9835±0.0408 | 0.8387 | 100.0% |
FAP | rs2075302 | T/C | Pancreas | 1.0000±0.0030 | 1.0251±0.0321 | 0.6606 | 100.0% |
KCNH7 | rs2068330 | C/G | LCL | could not be detected by PCR, not expressed in B lymphocytes | / | / | |
KCNH7 | rs2068330 | C/G | Thymus | could not be detected by PCR, not expressed in thymus | / | / | |
KCNH7 | rs2068330 | C/G | Pancreas | could not be detected by PCR, not expressed in pancreas | / | / |
n = 9 for LCLs, n = 13 for thymus, n = 6 for pancreas.
statistical significance as measured by the two-tailed student t test.
statistical power to detect a 40% difference of expression between alleles, at an α = 0.01.