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Time course of normalization of serum T4 and TSH with initial l-thyroxine treatment dose (modified from: LaFranchi & Austin. J Pediatr Endocrinol Metab 20:559-578, 2007[80].)
| Screening Program | l-thyroxine dose (mcg/kg/day) | Time to serum T4 > 10 ug/dL (days) | Time to serum TSH < 9.1 mU/L (days) |
|---|---|---|---|
| Quebec | 6 | 45-90 | |
| Toronto | 7-9 | 74 | |
| France | 8 | 15 | 60 |
| New England | 10 | 31 | |
| US (Pennsylvania) | 10-14 | 7 | 150 |
| Italy | 10-15 | 30 | 30 |
| US (Oregon) | 12-17 | 3 | 14 |
