Table 4.
Prevalence of molecular markers of anti-folate resistance among new episodes of P. falciparum malaria
| Characteristics | HIV-uninfected* (n = 352) |
HIV-infected* (n = 60) |
P-value |
|---|---|---|---|
| Prevalence of dhfr mutations | |||
| 51I | 179(99%)† | 60(100%) | 0.563 |
| 59R | 163 (91%)† | 56(93%) | 0.510 |
| 108N | 180(100%)† | 60 (100%) | |
| 164L | 1 (1%)† | 5 (8%) | 0.001 |
| Prevalence of dhps mutations | |||
| 437G | 172 (96%)† | 58 (97%) | 0.709 |
| 540E | 174(97%)† | 59 (99%) | 0.506 |
| Quintuple mutation‡ | 154 (86%)† | 55 (92%) | 0.222 |
*All HIV-uninfected participants were not receiving TS and all HIV-infected participants were receiving daily TS
† Assessed in a random sample of 180 episodes matched by malaria treatment and calendar time
‡ dhfr 51I/59R/108N + dhps 437G/540E mutations