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Diagram outlining 15-LOX-1 activity of NPD1 synthesis and bioactivity in RPE cells. Noxious stimuli activate 15-LOX-1, promoting the synthesis of NPD1 from DHA. NPD1 signaling modulates the activity and gene expression of proteins involved in pro- and anti-inflammatory signaling in apoptosis, ultimately fostering photoreceptor cell integrity and overall homeostasis.
