TABLE 1.
Modular enrichment analysis of genes differentially expressed by acute palmitate exposure
| Functional Group | Description | No. of Category | Pa | Pb | No. of Genes in Group |
|---|---|---|---|---|---|
| 4 | Apoptosis (programmed cell death) | 10 | 6.14 × 10−5 | 9.86 × 10−5 | 111 |
| 10 | Response to stress including inflammatory response | 5 | 8.13 × 10−3 | 5.49 × 10−3 | 82 |
| 16 | Oxidative stress-induced gene expression via Nrf2 and MafK | 3 | 1.02 × 10−2 | 1.74 × 10−2 | 6 |
| 18 | Activation of NFκB transcription factor | 3 | 1.47 × 10−2 | 2.66 × 10−2 | 8 |
| 19 | JAK-STAT cascade | 8 | 4.22 × 10−2 | 2.83 × 10−2 | 17 |
| 22 | SOCS protein and JAK-STAT cascade | 7 | 4.40 × 10−2 | 4.78 × 10−2 | 17 |
| 23 | MAP kinase phosphatase activity | 23 | 4.16 × 10−2 | 4.90 × 10−2 | 21 |
Data are for HepG2 cells treated with 1 mM palmitate for 6 h and compared with controls (BSA). We show selected DAVID functional annotation cluster analysis groups with a geometric mean P-value ≤ 0.05.
a
Median P-value of all categories in a functional group.
b
Geometric mean P-value of all categories in a functional group.