TABLE 4.

Genes showing discordant or >50% difference in response between oleate and palmitate adaptation in HepG2 cells

				% Amelioration
Gene Symbol	Entrez Gene ID	Gene Name	Fold Changea	Palmitate	Oleate
PIK3IP1	113791	Phosphoinositide-3-kinase interacting protein 1	2.58	32	100
DUSP8	1850	Dual specificity phosphatase 8	3.86	28	98
GPR109B	8843	G protein-coupled receptor 109B	3.21	2	91
ZNF295	49854	Zinc finger protein 295	2.12	5	84
SLC25A25	114789	Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25	2.36	6	84
GADD45B	4616	Growth arrest and DNA-damage-inducible, β	2.77	21	74
VNN2	8875	Vanin 2	2.00	−41	70
SERPINB8	5271	Serpin peptidase inhibitor, clade B (ovalbumin), member 8	2.29	9	63
EGR1	1958	Early growth response 1	5.66	3	56
TUBB2B	347733	Tubulin, β 2B	2.03	−8	56
SERPINE1	5054	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	2.10	−54	48
C10orf10	11067	Chromosome 10 open reading frame 10	2.40	−63	40
TANC1	85461	Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	3.08	88	38
GATA6	2627	GATA binding protein 6	2.60	108	31
AREG	374	Amphiregulin (schwannoma-derived growth factor)	3.66	91	25
KLF5	688	Kruppel-like factor 5 (intestinal)	2.18	81	4.33
IKBKE	9641	Inhibitor of κ light polypeptide gene enhancer in B-cells, kinase ϵ	2.40	57	−1
DUSP2	1844	Dual specificity phosphatase 2	3.31	50	−4
CYR61	3491	Cysteine-rich, angiogenic inducer, 61	2.11	50	−12
THBS1	7057	Thrombospondin 1	2.84	62	−71
SLC6A14	11254	Solute carrier family 6 (amino acid transporter), member 14	2.24	37	−73

Only genes with at least 2-fold upregulation by 1 mM palmitate exposure (6 h) in HepG2 cells and discordance between oleate and palmitate adaptation are shown.

^aFold change is taken from the acute 1 mM response to palmitate compared with control (BSA).