TABLE 1.
Characteristics of morbidly obese women before and 12 months after gastric bypass surgery and of age-matched healthy control subjects
| Gastric Bypass Patients (n = 19) |
|||
|---|---|---|---|
| Variable | Controls (n = 19) | Baseline | 12 months |
| Age (year) | 44 ± 4 | 41 ± 8 | 42 ± 8 |
| BMI (kg/m2) | 25 ± 4 | 46 ± 8a | 31 ± 5ab |
| Fat mass (kg) | NA | 67 ± 15 | 33 ± 8b |
| Lean mass (kg) | NA | 63 ± 14 | 46 ± 5b |
| Waist/hip ratio | 0.82 ± 0.1 | 0.95 ± 0.1a | 0.88 ± 0.1ab |
| Fasting glucose | 84 ± 10 | 100 ± 20a | 83 ± 5b |
| Fasting insulin (IU) | 9 ± 7 | 33 ± 16a | 11 ± 3ab |
| HOMA-IR | 1.7 ± 0.8 | 8.5 ± 5.7a | 2.3 ± 0.7ab |
| Total-C | 203 ± 48 | 147 ± 31a | 133 ± 24a |
| LDL-C | 121 ± 41 | 98 ± 29a | 81 ± 19ab |
| HDL-C | 59 ± 14 | 37 ± 10a | 46 ± 8ab |
| LDL/HDL | 2.2 ± 1.0 | 2.6 ± 0.7 | 1.9 ± 0.5b |
| HDL-TGa | NA | 19.4 ± 7.5 | 15.5 ± 5.3b |
| TGa | 112 ± 58 | 141 ± 105a | 84 ± 51b |
| RLP-C | 4.7 ± 2.4 | 7.4 ± 6.7a | 4.0 ± 3.6b |
| Apo A-I | 156 ± 23 | 108 ± 25a | 117 ± 26 |
| Apo A-II | 37 ± 8 | 24 ± 5a | 23 ± 5a |
| Apo E | 4.0 ± 0.8 | 3.6 ± 0.9 | 2.8 ± 0.6ab |
| LCAT mass (μg/ml) | NA | 9.3 ± 2.1 | 7.4 ± 1.6b |
| LCAT activityb | NA | 3.9 ± 1.0 | 2.7 ± 1.4b |
| CETP mass (μg/ml) | NA | 1.0 ± 0.3 | 1.1 ± 0.3 |
| CETP activityc | NA | 16.5 ± 19.2 | 2.8 ± 18.8b |
| ApoA-I-containing HDL subpopulations | |||
| Preβ-1 | 12.4 ± 6.5 | 14.3 ± 9.7 | 11.5 ± 7.3b |
| Preβ-2 | 2.3 ± 1.4 | 2.2 ± 1.7 | 1.9 ± 1.4 |
| α-1 | 27.4 ± 9.2 | 9.0 ± 4.7a | 17.3 ± 5.1ab |
| α-2 | 55.9 ± 11.0 | 39.1 ± 11.2a | 42.7 ± 11.0 |
| α-3 | 28.9 ± 4.7 | 24.8 ± 7.3 | 20.8 ± 7.9 |
| α-4 | 10.0 ± 3.1 | 10.4 ± 3.8 | 9.6 ± 4.0 |
| Preα-1 | 7.2 ± 3.2 | 1.9 ± 1.6a | 4.2 ± 2.4ab |
| Preα-2 | 8.0 ± 2.8 | 3.6 ± 1.8a | 4.8 ± 2.4a |
| Preα-3 | 1.9 ± 0.4 | 1.9 ± 0.8 | 1.7 ± 0.8 |
| Preα-4 | 1.0 ± 0.3 | 0.9 ± 0.5 | 0.9 ± 0.3 |
Values are mean ± SD (mg/dl) or as indicated. P ≤ 0.01 was selected as significantly different (Student's t-test). Letters indicate statistically significant difference from: (a) controls, (b) baseline. Conversion factor from mg/dl to mmol: for cholesterol, divide numbers by 38.88; for TG, divide numbers by 86.88.
a
Statistical test performed using log transformed values.
b
μg/ml/h CE increase in plasma.
c
μg/ml/h CE decrease in HDL.