TABLE 2.
Plasma octadecanoic acid alcohol and ketone concentrations (nM)a
| Alcohol Oxylipin | Isomer Comparisonb | Pre P-OM3 | Post P-OM3 | Fold Change | Pc |
|---|---|---|---|---|---|
| LA – HODE | |||||
| 9-HODE | A | 296 (250, 340) | 252 (220, 290) | 0.86 | 0.047 |
| 13-HODE | B | 741 (640, 860) | 641 (550, 750) | ||
| aLA – HOTE | |||||
| 9-HOTE | – | 8.07 (5.6, 12) | 7.65 (5, 12) | – | >0.05 |
| 13-HOTE | – | 6.82 (5.6, 8.2) | 5.84 (4.8, 7.1) | ||
| LA – KOTE | |||||
| 9-KODE | A | 88.2 (75, 100) | 74.9 (64, 88) | – | >0.05 |
| 13-KODE | B | 206 (180, 240) | 182 (160, 210) | ||
The mean and 95% CI of individual regioisomers after adjustment for subject and extraction batch. Abbreviations: AA, arachidonic acid; aLA, α-linolenic acid; EPA, eicosapentaenoic acid; HODE, hydroxyoctadecadienoic acid; HOTE, hydroxyoctadecatrienoic acid; KODE, ketooctadecadienoic acid; KOTE, ketooctadecadienoic acid; LA, linolenic acid; LOX, lipoxygenase; P-OM3, prescription omega-3 ethyl esters.
See Fig. 1 for associated 12- and 15-LOX pathways and the analogous AA and EPA regioisomers.
Regioisomers derived from the same parent FA with different letters differ significantly (P < 0.05) by Tukey's Honest Significant Differences test.
P-value of treatment effects on plasma concentrations.