TABLE 3.
Plasma eicosanoic and docosanoic acid alcohol and ketone concentrations (nM)a
| Alcohol Oxylipin | Isomer Comparisonb | Pre P-OM3 | Post P-OM3 | Fold Change | Pc |
|---|---|---|---|---|---|
| dgLA – HETrE | |||||
| 15-HETrE | – | 13.7 (12, 16) | 8.98 (7.6, 11) | 0.66 | 0.003 |
| AA – HETE | |||||
| 5-HETE | A | 81.9 (72, 93) | 66 (58, 75) | 0.8 | <0.0001 |
| 8-HETE | B | 33.9 (30, 38) | 26.1 (23, 29) | ||
| 9-HETE | C, B | 36.3 (32, 41) | 29.7 (26, 34) | ||
| 11-HETE | C | 43.4 (38, 49) | 34.1 (30, 39) | ||
| 12-HETE | D | 52.6 (47, 59) | 43.4 (38, 49) | ||
| 15-HETE | A | 84.7 (75, 96) | 67.4 (60, 76) | ||
| ω-alcohol | |||||
| 20-HETE | – | 4.35 (3.6, 5.3) | 4.27 (3.5, 5.2) | – | – |
| EPA – HEPE | |||||
| 5-HEPE | A | 12.4 (10, 15) | 71.1 (58, 88) | 5.7 | <0.0001 |
| 12-HEPE | B | 3.54 (2.9, 4.4) | 20.1 (16, 25) | ||
| 15-HEPE | B | 3.48 (2.8, 4.3) | 19.2 (16, 24) | ||
| DHA – HDoHE | |||||
| 17-HDoHE | – | 26.8 (21, 34) | 56 (44, 71) | 2.1 | 0.001 |
| AA – KETE | |||||
| 5-KETE | A | 19.7 (17, 23) | 16.3 (14, 19) | 0.83 | 0.03 |
| 15-KETE | B | 63.1 (54, 74) | 53.8 (46, 63) | ||
Mean and 95% CI of individual regioisomers after adjustment for subject and extraction batch. Abbreviations: AA, arachidonic acid; aLA, α-linolenic acid; dgLA, dihomo-γ-linolenic acid; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; FA, fatty acid; HDoHE, hydroxydocosahexaenoic acid; HEPE, hydroxyeicosapentaenoic acid; HETE, hydroxyeicosatetraenoic acid; HETrE, hydroxyeicosatrienoic acid; HODE, hydroxyoctadecadienoic acid; KETE, ketoeicosatetraenoic acid; LA, linolenic acid; LOX, lipoxygenase; P-OM3, prescription omega-3 ethyl esters.
See Fig. 1 and supplemental Fig. I (5-LOX) for associated pathways for each oxylipin regioisomer.
Regioisomers derived from the same parent FA with different letters differ from each other significantly (P < 0.05) by Tukey's Honest Significant Differences test.
P value of treatment effects on plasma.