TABLE 4.
Concentration of plasma epoxides and vicinal diols in nMa
| Epoxide Oxylipin | Baseline | n-3 FA | Fold Change | Pc | Vicinal Diol Oxylipin | Baseline | n-3 FA | Fold Change | Pc | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| LA – EpOME | LA – DiHOME | ||||||||||
| 9(10)-EpOME | 83.4 (72, 97) | 79.5 (69, 92) | – | >0.05 | 9,10-DiHOME | A | 197 (170, 230) | 220 (190, 260) | – | >0.05 | |
| 12(13)-EpOME | 83.1 (72, 96) | 76.9 (66, 89) | >0.05 | 12,13-DiHOME | B | 18.1 (16, 21) | 16.7 (14, 19) | ||||
| aLA – EpODE | aLA – DiHODE | ||||||||||
| 9(10)-EpODE | Ab | 5.5 (4.4, 6.9) | 5.32 (4.3, 6.6) | – | >0.05 | 9,10-DiHODE | A | 1.38 (1.1, 1.7) | 1.6 (1.3, 2) | – | >0.05 |
| 12(13)-EpODE | B | 1.44 (1.2, 1.8) | 1.39 (1.1, 1.7) | 12,13-DiHODEd | – | – | |||||
| 15(16)-EpODE | C | 9.19 (7.4, 11) | 8.09 (6.5, 10) | 15,16-DiHODE | B | 14.5 (12, 18) | 16.9 (13, 21) | ||||
| AA – EpETrE | AA – DiHETrE | ||||||||||
| 5(6)-EpETrEe | – | – | 5,6-DiHETrE | A | 20.1 (18, 23) | 15.1 (13, 17) | 0.81 | <0.0001 | |||
| 8(9)-EpETrE | A | 16.4 (14, 19) | 14.7 (13, 17) | – | >0.05 | 8,9-DiHETrE | B | 11.7 (10, 13) | 9.3 (8.2, 11) | ||
| 11(12)-EpETrE | B | 61.7 (54, 71) | 56.4 (49, 64) | 11,12-DiHETrE | C | 3.98 (3.5, 4.5) | 3.31 (2.9, 3.8) | ||||
| 14(15)-EpETrE | C | 28.5 (25, 33) | 26.1 (23, 30) | 14,15-DiHETrE | D | 2.57 (2.3, 2.9) | 2.28 (2, 2.6) | ||||
| EPA – EpETE | EPA – DiHETE | ||||||||||
| 14(15)-EpETE | A | 3.78 (2.8, 5.2) | 17.5 (13, 24) | 4.7 | <0.0001 | 14,15-DiHETE | A | 2.14 (1.8, 2.6) | 8.6 (7.2, 10) | 4.1 | <0.0001 |
| 17(18)-EpETE | B | 5.81 (4.2, 8) | 28 (20, 38) | 17,18-DiHETE | B | 8.85 (7.4, 11) | 36.3 (30, 43) | ||||
| DHA – EpDoPE | DHA – DiHDoPE | ||||||||||
| 16(17)-EpDoPE | A | 11.1 (7.8, 16) | 24.6 (17, 35) | 2.1 | 0.0003 | 16,17-DiHDoPEf | – | – | 2.1 | 0.017 | |
| 19(20)-EpDoPE | A | 11.9 (8.3, 17) | 24.2 (17, 35) | 19,20-DiHDoPE | 3.33 (2.4, 4.6) | 7.00 (5.1, 9.7) | |||||
Means and 95% CI of individual regioisomers after adjustment for subject and extraction batch. Abbreviations: AA, arachidonic acid; aLA, α-Linolenic acid; DHA, docosahexaenoic acid; DiHDoPE, dihydroxydocosapentaenoic acid; DiHETE, dihydroxyeicosatetraenoic acid; DiHETrE, dihydroxyeicosatrienoic acid; DiHODE, dihydroxyoctadecadienoic acid; DiHOME, dihydroxyoctadecamonoenoic acid; EPA, eicosapentaenoic acid; EpDoPE, epoxyedocosapentaenoic acid; EpETE, epoxyeicosatetraenoic acid; EpETrE, epoxyeicosatrienoic acid; EpOME, epoxyoctadecamonoenoic acid; LA, linoleic acid.
See Fig. 2 for associated pathways for each oxylipin regioisomer.
Regioisomers derived from the same parent FA with different letters differ from each other significantly (P < 0.05) by Tukey's Honest Significant Differences test.
P value of treatment effects on plasma concentrations.
Below limit of detection.
Surrogate recovery failed quality control due to lactone formation (See Fig. 2).
No commercial standard available.