Table 4. Fate of Double Heart Transplants With Three-Day Course of 1.28 mg/kg/d Intramuscular FK.

		Time Sequence Over 14-Day Period
Group	Strain Combinations	1st HTx on Day 0 and Survival (d)	FK on Days 4, 5, and 6	HTx on Day 14 and Survival (d)	Meaning of Group
1	1st HTx, ACI-LEW	Yes (6, 6, 6, 6, 7, 7, 7)	No	No	Untreated control, same as group 1, Table 1
19	1st HTx, BN-LEW	Yes (11, 11, 11, 12, 12, 13)	No	No	Untreated control, with BN-LEW strain combination
20	Delayed HTx, ACI-LEW	No	Yes	Yes (9, 10, 10, 11)	Measures effect of 3 days' treatment 7-10 days before delayed grafting
21	Delayed HTx, BN-LEW	No	Yes	Yes (27, 34)	Measures effect of 3 days' treatment 7-10 days before delayed grafting with easier BN-LEW combination
22	1st HTx, ACI-LEW	Yes (>37, 63, 64, 70)	Yes		Confirms group 18, Table 3, and conditions recipient for 2nd graft
	2nd HTx, ACI-LEW			Yes (25, 41, 49, 56)	Test of donor-specific tolerance without further FR treatment, ACI donor P < .01 v group 20
23	1st HTx, ACI-Lew	Yes (48, 60)	Yes		Same result with 1st Htx as in group 22
	2nd HTx, BN-LEW			Yes (14, 15)	Minimal survival advantage for 2nd graft using BN donor

Test groups are groups 22 and 23; all others are controls.

Abbreviation: HTx, heart transplant.