Table 3.
Pathology Findings In Liver Rescue Patients In Whom CyA or Steroid Toxicity Was the Reason for the Switch or In Whom Rejection Was Suspected by the Clinicians
Patient | Pathology of Previous Failed Grafts | Pre-FK 506 Biopsy Diagnosis | Post-FK 506 Biopsy Diagnosis | Graft Status |
---|---|---|---|---|
J.G. | None | Treated ACR, repair of harvesting | Chronic cholestasis | Functioning |
J.B. | GX1; PNF; ischemic | Ischemic Injury | Minimal cholestasis | Functioning |
P.M.* | None | Mild ACR, sepsis | NA | Functioning |
J.C. | GX1; PNF; ischemic | Mild ACR, preservation injury | NA | Functioning |
J.M. | None | Severe preservation injury | Repair of preservation injury | Functioning |
A.T.* | GX1; duct obstruction | Ischemic Injury | NA | Functioning |
F.G. | None | Severe preservation injury | Repair of preservation injury | Functioning |
C.K.* | None | Mild ACR, reactive changes | Nonspecific changes | Functioning |
T.R. | None | Nonspecific changes | Microgranulomas | Functioning |
A.M.* | None | NA | NA | Functioning |
J.S.* | None | Sepsis, ischemic injury | Repair of ischemic injury | Functioning |
D.M.* | None | NA | Severe ischemic injury | Died |
G.S. | GX 1; PNF; ischemic | Mild ACR, preservation injury | Cholangitis, sepsis | Died: sepsis ARDS |
Abbreviations: PNF, primary nonfunction; GX, graft; ACR, acute cellular rejection; NA, not available; ARDS, adult respiratory distress syndrome.
Patients switched to FK 506 because of renal failure (CyA toxicity) or steroid complications.