Table 6.

Histologic Findings in Organs That are Potential Sites of FK 506 Toxicity In Patients Who Died While on Therapy

Patient	Liver	Kidney	Pancreas	Blood Vessels	Other
D.M.	Microabscesses; no rejection	Mild arterial and arteriolonephrosclerosis; Fabray’s heterozygote	None	Atherosclerosis of LAD; hypertensive pulmonary arteriopathy	Severe coronary artery atherosclerosis
M.S.	Focal infarcts and congestion; minimal rejection	Marked tubular vacuolization; congestion	None	Focal mural necrosis of arteries in perinephric fat of left renal pelvis	Cerebellar hemorrhage
A.N.*	Centrilobular congestion and hemorrhage	Mild tubular vacuolization; no rejection	Acute pancreatitis with acinar dilatation and focal arterial necrosis	Focal thrombosis and necrosis of pancreatic arteries	Severe necrotizing pneumonia (polymicrobial)
G.S.	Congestion and focal mild rejection	Minimal tubular vacuolization; changes of ATN	Autolysis with focal pancreatitis; mild interstitial fibrosis	Infarcted colonic epiploic with necrotic artery	Subhepatic abscess; organizing diffuse alveolar damage of lungs
L.S.	Congestion; mild focal rejection	Focal infarct; marked tubular vacuolization; occasional polar arteriolar thrombosis	Acute hemorrhagic pancreatitis with arterial necrosis and thrombosis	Intraluminal fibrin thrombi in pulmonary arteries, submucosal veins of colon and renal polar arterioles	Large pulmonary thromboembolus

Abbreviations: ATN, acute tubular necrosis; LAD, left anterior descending coronary artery.

^*Patient was taken off FK 506 before death because of mistaken diagnosis of hepatitis B.