Table 2.
Hemodynamic Profile Before, During, and After Administration of a Loading Dose of FK 506 (0.15 mg · kg−1)
| Before FK 506 |
FK + 15 | FK + 30 | FK + 60 | FK + 120 | |
|---|---|---|---|---|---|
| MAP | 77 ± 10 | 77 ± 8 | 77 ± 9 | 76 ± 9 | 78 ± 11 |
| HR | 96 ± 14 | 93 ± 13 | 92 ± 13 | 93 ± 14 | 93 ± 15 |
| MPAP | 19 ± 4 | 18 ± 4 | 18 ± 4 | 19 ± 4 | 20 ± 4 |
| RVSP | 36 ± 7 | 37 ± 10 | 35 ± 9 | 35 ± 10 | 37 ± 9 |
| RVDP | 8 ± 5 | 9 ± 5 | 8 ± 5 | 9 ± 5 | 9 ± 5 |
| PCWP | 10 ± 4 | 11 ± 4 | 11 ± 3 | 11 ± 3 | 11 ± 2 |
| CVP | 10 ± 4 | 10 ± 4 | 10 ± 4 | 10 ± 3 | 11 ± 3 |
| CI. | 4.5 ± 1.4 | 4.4 ± 1.5 | 4.3 ± 1.4 | 4.4 ± 1.5 | 3.9 ± 1.5 |
| SVI | 48 ± 16 | 48 ± 18 | 47 ± 15 | 48 ± 16 | 43 ± 18 |
| RVEF | 50 ± 9 | 48 ± 11 | 48 ± 9 | 48 ± 10 | 46 ± 10 |
| LVSWI | 43 ± 15 | 43 ± 18 | 42 ± 16 | 42 ± 15 | 39 ± 18 |
| RVSWI | 6 ± 3 | 5 ± 4 | 5 ± 3 | 6 ± 2 | 5 ± 3 |
| SVRI | 1317 ± 539 | 1368 ± 514 | 1376 ± 444 | 1337 ± 465 | 1580 ± 704 |
| PVRI | 167 ± 95 | 163 ± 101 | 155 ± 104 | 179 ± 114 | 229 ± 201 |
| BT | 34.3 ± 1.0 | 34.4 ± 1.1 | 34.4 ± 1.1 | 34.4 ± 1.2 | 34.5 ± 1.2 |
Note: Values are mean ± SD. Hemodynamic profiles remained unchanged during the observation period.
Abbreviations: MAP (mmHg), mean arterial pressure; HR (beat · min−1), heart rate; MPAP (mmHg), mean pulmonary artery pressure; RVSP (mmHg), right ventricular systolic pressure; RVDP (mmHg), right ventricular diastolic pressure; PCWP (mmHg), pulmonary capillary wedge pressure; CVP (mmHg), central venous pressure; CI (L · min−1 · m−2), cardiac index; SVI (ml · m−2), stroke volume index; RVEF (%), right ventricular ejection fraction; LVSWI (g · m · m−2), left ventricular stroke work index; RVSWI (g · m · m−2), right ventricular stroke work index; SVRI (dynes · sec · cm−5 · m−2), systemic vascular resistance index; PVRI (dynes · sec · cm−5 · m−2), pulmonary vascular resistance index; and BT (°C), body temperature.