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. Author manuscript; available in PMC: 2010 Jul 14.
Published in final edited form as: Islets. 2009 Nov;1(3):273–275. doi: 10.4161/isl.1.3.9781

Figure 2. 17α-estradiol protects islet survival.

Figure 2

(A) Relative luciferase activity in MIN6 cells transfected with an ERE reporter construct and treated with E2 (β-E2) or 17α-estradiol (α-E2) (10−8M). (B) Percentage of apoptotic cells in cultured human islets. Islets were treated with E2 (β-E2) or 17α-estradiol (α-E2) (10−8M) for 48 h, followed by exposure to H2O2 (100μM) for the last 5 hours. Apoptosis was assessed by nuclear morphology as described (3). Values represent the mean ± SE of five independent experiments. * P<0.05, ** P<0.01.