Table 1.
Female mice lacking AR expression in GCs have age-related reduced fertility
| Genotype | n | Litter | Pups | Pups/litter | Litter/female |
|---|---|---|---|---|---|
| 8- to 9-wk-old animals | |||||
| GC AR −/− | 8 | 17 | 48 | 2.82 ± 0.2a | 2.13 ± 0.22b |
| WT | 8 | 28 | 200 | 7.14 ± 0.29 | 3.5 ± 0.19 |
| GC AR +/− | 8 | 28 | 195 | 6.96 ± 0.28 | 3.5 ± 0.19 |
| 24- to 25-wk-old animals | |||||
| GC AR −/− | 6 | 10 | 16 | 1.6 ± 0.23a | 1.66 ± 0.21a |
| WT | 6 | 20 | 119 | 5.95 ± 0.25 | 3.33 ± 0.21 |
| GC AR +/− | 6 | 19 | 113 | 5.95 ± 0.42 | 3.17 ± 0.16 |
WT males were mated for 12 wk with 8- to 9-wk-old, or 24- to 25-wk-old WT and GC-specific AR −/− and +/− female animals. Both the number of litters and the number of pups per litter were determined. Data are represented as mean ± se.
a
P ≤ 0.01;
b
P ≤ 0.05 for GC AR −/− vs. WT and GC AR +/− mice using ANOVA.